Cell adhesion by aqueous extract of human placenta used as wound healer

Indian Journal of Experimental Biology

Vol. 45, August 2007, pp. 732-738

Sangeeta Nath & Debasish Bhattacharyya

Received 3 January 2007

Aqueous extract of human placenta, used as wound healer, has shown significant cell adhesion property on mouse peritoneal macrophages and P388D1 cultured macrophage cell line. This property was offered primarily by fibronectin type III like peptide present in the extract and is comparable to fibronectin on a molar basis. The peptide induce adhesion of cell through cell surface receptors having Kd = 2.8±0.9 ´ 10-5 M suggesting weak binding. This is in support of integrins receptors that typically exhibit low affinities. Cell adhesion was partially inhibited by Arg-Gly-Asp (RGD) peptide, anti-β1 integrin suggesting that integrin β1 receptors have roles to play in the process.

Courtesy: 

1) Indian Journal of Experimental Biology

http://www.niscair.res.in/sciencecommunication/researchjournals/rejour/ijeb/ijeb2k7/ijeb_aug07.asp#p10

2) PubMed

http://www.ncbi.nlm.nih.gov/pubmed/17877151