Melagenina Plus for the treatment of Vitiligo - A HPE Therapy from Cuba

By Swapan Das, Calcutta
What is Vitiligo?

Vitiligo of the hand in a dark-skinned individual

Vitiligo (vit-ill-EYE-go) is a disorder in which white patches of skin appear on different parts of the body. This happens because the cells that make pigment (color) in the skin are destroyed. These cells are called melanocytes (ma-LAN-o-sites). Vitiligo can also affect the mucous membranes (such as the tissue inside the mouth and nose) and the eye. The global prevalence of vitiligo is 1 to 2 per cent including among the white skin communities. However, epidemiologically higher cases are recorded in India and Mexico. The most common form is non-segmental vitiligo.

There had been several studies on HPE therapy to cure or control the Vitiligo. But it needs further evaluation of the efficacy of HPE therapy, which may offer a cost-effective way of improving the treatment of vitiligo. 

MELAGENINA PLUS

Melagenina Plus is manufactured in Centro de Histoterapia, Havana, Cuba. Melagenina Plus ( Melagenina + Calcium Chloride ) is an alcoholic extract of human placenta, a pharmacological product that has the property to increase the reproduction of melanocytes in the borders or inside the acronic areas of the sick persons, as well as to acelerate the process of production of melanin, that is why it has become a popular therapy for Vitiligo. According to the Cuban doctor Carlos Manuel Miyares Cao and his team placental alcohol extracts with calcium added can be very effective and innocuous for the vitiligo treatment. HPE Blog recently shared this team's study with the readers (HPE for the treatment of Vitiligo - A study from Cuba.). 

Melagenina Plus is a topical lotion for external application. The product claims to have no side effects and is easy to apply. There are reports which claims International clinical trials have reported 84-per cent success rate with no incidence of relapse. It has been pronounced safe for use by even sensitive groups such as children, pregnant and lactating women and geriatric patients. The drug needs to be used in the stable vitiligo type and not in the active stage. It is said that in all, over 13,000 patients from 123 countries have been treated by Melagenina Plus in the initial 15 years of its launch in Cuba.

Important Message For Vitiligo Patients & Followers:  

• Vitiligo is difficult to treat. To be honest at the time of writing this article for this blog, strictly speaking there is no 100% cure for vitiligo. The product featured here or other treatments may reduce the symptoms but as of now its still not 100% curable.

• Melagenina Plus is not legal for use in the USA. Its being a Human Placental Extract product, USFDA doesn't approves it.

• Please do not treat this article as the recommendation/prescription for the vitiligo treatment. Please consult your doctor (you may pass this information of HPE treatment in case he/she is not aware of it).

• Visit Vitiligo Support International which is a patient driven 501(c)(3) nonprofit organization offering a comprehensive resource of vitiligo education, research and awareness for those whose lives have been affected by vitiligo.

• Visit Vitiligo - PubMed Health for further information on Vitiligo.

• NIAMS - USA for further information on vitiligo.

• There had been several studies on Human Placenta Extract therapy to cure or control the Vitiligo, a few references could be found in our Research Articles category. Perhaps it needs more evaluation of the scientific research which is going on this domain with respect to the Vitiligo therapy.

• If HPE therapy has helped you in fighting against Vitiligo then we want to hear your story so that we can share here.

Reference & Courtesy:

• Centro de Histoterapia Placentaria, La Habana, Cuba --> TREATMENT OF VITILIGO - MELAGENINA PLUS (For Information on Melagenina Plus)
• Author James Heilman, MD - Wikipedia (For Vitiligo Image)
• NIAMS - USA (For Vitiligo Definition)

Human Placental Extract Products - Part I

By Swapan Das, Calcutta

The internet is floated with the information & advertisements on human placental extract products (HPE). And the products range from the prescribed drugs domain to cosmetic domain. We have come across that human placental based drugs are readily approved in the oriental countries like Japan, South Korea. The Human Placental Extract has been in use in Japan for decades. The Japan's National Health Insurance covers placental treatments for liver disease and symptoms of menopause. The HPE products manufactured in Japan are approved by the Govt. of Japan which follows stringent safety measures as per the Japanese Pharmacopoeia (JP) which is equivalent to the safety measures taken in US and western countries. It’s been noticed that human placental extract therapy is an accepted therapy in Oriental, South East Asian countries whereas with harmonization of EU (European Union ) laws and regulations (follows US  FDA rules  FOR BIOLOGICALS), its use is

Human Placental Extract Products - Part II

By Swapan Das, Calcutta

<Continued from: Human Placental Extract Products - Part I>

Here we showcase a few of the human placental extract products commercially available which are not necessary prescribed drugs and may cater to "cosmetic domain". One can visit the website of Korea Genetic Pharmaceutical Co., Ltd which gives a good insight to the kind of work and acceptance of human placental extract products have in South Korea.

For a general awareness, we are incorporating the following list to showcase a glimpse of the kind of products that are available across the globe. The list doesn't claims to either to be "complete" or "updated". A few such commercial products are:

MELSMON - The Japanese Human Placental Extract

By Swapan Das, Calcutta

In 1950, a group of physicians researching “Tissue Therapy” got together and established the “Tissue Therapy Research Institute”. After developing Placenta Extract injections in 1956 they founded “Melsmon Pharmaceutical Company Limited which obtained government approval and began manufacture and sale of Melsmon injection as a treatment for menopausal, disorders and failed lactations.

The website of Melsmon claims:

Melsmon Cell Revitalization Extract has been highly accepted by the medical society in Japan. Melsmon is listed on the Nippon Health Insurance drug tariff (NHI). As an approved pharmaceutical product listed on the NHI drug tariff, the Japanese Government actually pays for suitable Japanese citizens to use Melsmon.

The readers may refer the following links to know more about this product and the manufacturer:

• Official Website of Melsmon
• Japanese Govt. Approval
• Dr Kentaro Yoshida (Japan) on Human Placental Extract & Melsmon

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Laennec – Japanese Human Placental Extract

By Swapan Das, Calcutta

Laennec Placenta - Japan

LAENNEC PLACENTA - A human placenta based product, is the result of research done at JBP research center in Kurume, Japan headed by Dr. Akira Yagi. Established in 1936, Japan Bio Products Co., Ltd. today is the world's largest manufacturer of Pharmaceuticals derived from Human Placental extracts by volume. Licensed by Japanese Ministry of Health & welfare in 1974 to commercialize Laennec inj., a drug developed by proprietary extraction process, is used to treat liver dysfunction in patients suffering from Liver Cirrhosis & Hepatitis, with GMP certification. Current manufacturing facilities include Kurume factory in Japan & Eumsung in Seoul, South Korea. 

LAENNEC is said to be a government subsidized drug for Japanese patients seeking treatment for Hepatitis and liver cirrhosis. The Japan’s National Health Insurance covers placental treatments for liver disease and symptoms of menopause. It is a “specialized designated drug”, a prescribed drug, holds license as an ethical drug. This drug is manufactured under the supervision of pharmaceutical affairs law of Japan as per the GMP guidelines. It claims to have set up a vast global network, touching the boundaries of nations like Japan, Korea, Russia, USA, Singapore, Malaysia, Taiwan, and China. 

Readers may visit the following links to know more about this Product and the Manufacturer:

Website of Japan Bio Products Ltd

JBP SEA (South East Asia – Malaysia)

AsianWhiteSkin – Philippines

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PLACENTREX - Indian Human Placental Extract

Product Profile with latest Indications Coming Soon!

We are awaiting for the website update from the manufacturer of this Indian product. This blog contains lot of information on Placentrex, which the interested readers may refer to. You may use the "Search This Blog" search box supplied on the right sidebar of the blog to search for information related to 'Placentrex'.

For any inquiry on this product, you can mail us at:placentrex@gmail.com

[BACK TO PART-I]

MELAGENINA PLUS – Cuban Human Placental Extract

Melagenina Plus is manufactured in Centro de Histoterapia, Havana, Cuba. Melagenina Plus ( Melagenina + Calcium Chloride ) is an alcoholic extract of human placenta, a pharmacological product that has the property to increase the reproduction of melanocytes in the borders or inside the acronic areas of the sick persons, as well as to acelerate the process of production of melanin, that is why it has become a popular therapy for Vitiligo. According to the Cuban doctor Carlos Manuel Miyares Cao and his team placental alcohol extracts with calcium added can be very effective and innocuous for the vitiligo treatment. HPE Blog recently shared this team's study with the readers (HPE for the treatment of Vitiligo - A study from Cuba)

Melagenina Plus is a topical lotion for external application. The product claims to have no side effects and is easy to apply. There are reports which claims International clinical trials have reported 84-per cent success rate with no incidence of relapse. It has been pronounced safe for use by even sensitive groups such as children, pregnant and lactating women and geriatric patients. The drug needs to be used in the stable vitiligo type and not in the active stage. It is said that in all, over 13,000 patients from 123 countries have been treated by Melagenina Plus in the initial 15 years of its launch in Cuba.

For further information on Vitiligo & Melagenina Plus Therapy:

• Melagenina Plus for the treatment of Vitiligo - A HPE Therapy from Cuba

Reference & Courtesy:

• Centro de Histoterapia Placentaria, La Habana, Cuba --> TREATMENT OF VITILIGO - MELAGENINA PLUS